7th April celebrated as World Health Day.

World Intellectual Property Day is observed annually on 26 April. The event was established by the World Intellectual Property Organization (WIPO) in 2000 to "raise awareness of how patents, copyright, trademarks and designs impact on daily life" and "to celebrate creativity, and the contribution made by creators and innovators to the development of societies across the globe". 26 April was chosen as the date for World Intellectual Property Day because it coincides with the date on which the Convention Establishing the World Intellectual Property Organization entered into force in 1970.

World Day For Animals In Laboratories (also known as World Lab Animal Day) is observed every year on 24 April. The surrounding week has come to be known as "World Week for Animals In Laboratories". The National Anti-Vivisection Society (NAVS) describe the day as an "international day of commemoration" for animals in laboratories.

Italy's Liberation Day (Festa della liberazione), also known as the Anniversary of the Liberation (Anniversario della liberazione d'Italia), Anniversary of the Resistance (anniversario della Resistenza), or simply 25 April is a national Italian holiday commemorating the end of the Italian Civil War and the end of Nazi occupation of the country during World War II. This is distinct from the Republic Day (Festa della Repubblica) which takes place on 2 June.

World Day for Safety and Health at Work is a UN international day that is celebrated every 28 April.

World Malaria Day (WMD) is an international observance commemorated every year on 25 April and recognizes global efforts to control malaria. Globally, 3.3 billion people in 106 countries are at risk of malaria. In 2012, malaria caused an estimated 627,000 deaths, mostly among African children. Asia, Latin America, and to a lesser extent the Middle East and parts of Europe are also affected.

World Autism Awareness Day celebrated on 2nd April

Ambedkar Jayanti or Bhim Jayanti is an annual festival observed on 14 April to commemorate the memory of B. R. Ambedkar. It marks Ambedkar's birthday in 1891 and since 2015 is an official public holiday throughout India. Dr. Ambedkar Jayanti is celebrated not only in India but also more than in 65 countries.

International Dance Day was introduced in 1982 by the International Dance Council (CID, Conseil International de la Danse), a UNESCO partner NGO, and is celebrated yearly, on April 29. The date is not linked to a particular person or a particular form of dance, although it's also the day when the French dancer and ballet master Jean-Georges Noverre was born. The main purpose of Dance Day events is to attract the attention of the wider public to the art of dance. Emphasis should be given to addressing a new public, people who do not follow dance events during the course of the year.

International Day for Mine Awareness celebrated on April 4.